Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction

@article{Stuart2005LocalizationOM,
  title={Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction},
  author={Jeffrey A. Stuart and Sabine Mayard and Kazunari Hashiguchi and Nadja C. de Souza-Pinto and Vilhelm A. Bohr},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={3722 - 3732}
}
Mitochondrial DNA (mtDNA) contains high levels of oxidative damage relative to nuclear DNA. A full, functional DNA base excision repair (BER) pathway is present in mitochondria, to repair oxidative DNA lesions. However, little is known about the organization of this pathway within mitochondria. Here, we provide evidence that the mitochondrial BER proteins are not freely soluble, but strongly associated with an inner membrane-containing particulate fraction. Uracil DNA glycosylase, oxoguanine… CONTINUE READING