Localization of metalloporphyrin-induced "specific" enhancement in experimental liver tumors: comparison of magnetic resonance imaging, microangiographic, and histologic findings.

@article{Ni1995LocalizationOM,
  title={Localization of metalloporphyrin-induced "specific" enhancement in experimental liver tumors: comparison of magnetic resonance imaging, microangiographic, and histologic findings.},
  author={Yicheng Ni and Guy Marchal and Jie Yu and Gregorius Lukito and Carine Petr{\'e} and Martine Wevers and AlbertL. Baert and Wolfgang M. Ebert and Christoph Stephan Hilger and Florian Maier},
  journal={Academic radiology},
  year={1995},
  volume={2 8},
  pages={
          687-99
        }
}
RATIONALE AND OBJECTIVES We investigated the tumor specificity of gadolinium mesoporphyrin (Gd-MP) and manganese tetraphenylporphyrin (Mn-TPP) as magnetic resonance (MR) imaging contrast agents. METHODS Fifteen rats with multiple hepatocellular carcinomas and eight rats with implanted Novikoff hepatomas were given intravenous injections of either Gd-MP or Mn-TPP at 0.05 mmol/kg, which was compared with nonspecific gadopentetate dimeglumine (0.3 mmol/kg). T1-weighted spin-echo images were… CONTINUE READING
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