Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.

@article{Becker2010LocalizationOM,
  title={Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.},
  author={Helen Becker and Nilufar Mohebbi and Angelica Perna and Vadivel Ganapathy and Giovambattista Capasso and Carsten A Wagner},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 1},
  pages={F141-54}
}
The monocarboxylate transporter family (MCT) comprises 14 members with distinct transport properties and tissue distribution. The kidney expresses several members of the MCT family, but only little is known about their exact distribution and function. Here, we investigated selected members of the MCT family in the mouse kidney. MCT1, MCT2, MCT7, and MCT8 localized to basolateral membranes of the epithelial cells lining the nephron. MCT1 and MCT8 were detected in proximal tubule cells whereas… CONTINUE READING

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