Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland.

@article{Nishino1995LocalizationOM,
  title={Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland.},
  author={Tomoya Nishino and J{\"u}rgen Bernhagen and Hideo Shiiki and Thierry Calandra and Kenji Dohi and Richard Bucala},
  journal={Molecular medicine},
  year={1995},
  volume={1 7},
  pages={
          781-8
        }
}
BACKGROUND Macrophage migration inhibitory factor (MIF) was one of the first lymphokine activities to be discovered and was described almost 30 years ago to be a soluble factor(s) produced by activated T lymphocytes. In more recent studies, MIF has been "rediscovered" to be an abundant, pre-formed constituent of the anterior pituitary gland and the macrophage, and to be a critical component in the host response to septic shock. Pituitary-derived MIF enters the circulation after infectious or… CONTINUE READING