Localization of mRNA and receptor binding sites for the alpha 1a-adrenoceptor subtype in the rat, monkey and human urinary bladder and prostate.

@article{Walden1997LocalizationOM,
  title={Localization of mRNA and receptor binding sites for the alpha 1a-adrenoceptor subtype in the rat, monkey and human urinary bladder and prostate.},
  author={Paul D. Walden and Margaret M. Durkin and Herbert Lepor and John M. Wetzel and Charles Gluchowski and Eric L. Gustafson},
  journal={The Journal of urology},
  year={1997},
  volume={157 3},
  pages={1032-8}
}
PURPOSE To localize the mRNAs and receptor binding sites for the alpha 1a/A, alpha 1b/B and alpha 1d/D- adrenoceptor (AR) subtypes in the rat, monkey and human urinary bladder and prostate. MATERIALS AND METHODS alpha 1-AR mRNAs were localized on slide mounted tissue sections by in situ hybridization using [35S]-labeled subtype specific oligonucleotide probes. alpha 1-AR receptor binding sites were localized on slide mounted tissue sections by competitive displacement of [3H]-prazosin using… CONTINUE READING

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