Localization of insulin-like growth factor binding protein-4 expression in the developing and adult rat brain: analysis by in situ hybridization.

@article{Brar1993LocalizationOI,
  title={Localization of insulin-like growth factor binding protein-4 expression in the developing and adult rat brain: analysis by in situ hybridization.},
  author={Anoop K. Brar and Steven D. Chernausek},
  journal={Journal of neuroscience research},
  year={1993},
  volume={35 1},
  pages={
          103-14
        }
}
We have previously isolated insulin-like growth factor binding protein-4 (IGFBP-4) from media conditioned by a neuronal cell line and have detected IGFBP-4 mRNA in selected regions of the developing and adult rat brain by Northern blot analysis. In this study, the ontogeny and regional distribution of IGFBP-4 expression were determined by in situ hybridization histochemistry. While IGFBP-4 mRNA expression at embryonic day 15 was restricted to choroid plexus primordium and meninges, by embryonic… CONTINUE READING

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