Localization of gene for human p53 tumour antigen to band 17p13

  title={Localization of gene for human p53 tumour antigen to band 17p13},
  author={M. Isobe and B. Emanuel and D. Givol and M. Oren and C. Croce},
  • M. Isobe, B. Emanuel, +2 authors C. Croce
  • Published 1986
  • Biology, Medicine
  • Nature
  • Recently the gene for the cellular tumour antigen p53, a phos-phoprotein found in increased concentration in a variety of human cells1, has been mapped to region 17q22 by in situ hybridization techniques and has been shown to translocate to the chromosome carrying the translocation [t(15 ; 17)] associated with acute pro-myelocytic leukaemia (APL)2. Based on this finding it has been postulated that this gene has a role in the pathogenesis of APL2. Here we present evidence that the gene for p53… CONTINUE READING
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