Localization of gene for human p53 tumour antigen to band 17p13

@article{Isobe1986LocalizationOG,
  title={Localization of gene for human p53 tumour antigen to band 17p13},
  author={Masaharu Isobe and Beverly S Emanuel and David Givol and Moshe Oren and Carlo Maria Croce},
  journal={Nature},
  year={1986},
  volume={320},
  pages={84-85}
}
Recently the gene for the cellular tumour antigen p53, a phos-phoprotein found in increased concentration in a variety of human cells1, has been mapped to region 17q22 by in situ hybridization techniques and has been shown to translocate to the chromosome carrying the translocation [t(15 ; 17)] associated with acute pro-myelocytic leukaemia (APL)2. Based on this finding it has been postulated that this gene has a role in the pathogenesis of APL2. Here we present evidence that the gene for p53… 
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493 Citations
Highly Influential Citations
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Background Citations
117
Methods Citations
3

493 Citations

Chromosome 17p and p53 changes in lymphoma
TLDR
It is suggested that acquisition of changes in the short arm of chromosome 17, which may be interrelated with the p53 gene, may carry a poor prognosis in patients with non‐Hodgkin's lymphoma.
Mutations of the P53 Gene in Acute Leukemias: A Report on 207 Cases
TLDR
The great majority of point mutations were found in exon 5 to 8 of the p53 gene, and were clustered in four mutations “hotspots” situated between codons 130 and 290.
Localization of the tumour protein, TP53, on porcine chromosome 12q12-q14.
TLDR
Results confirm the localization of an evolutionary conserved linkage group on porcine chromosome 12 which is localized in man on chromosome 17, in cattle on chromosome 19, and in mice on chromosome 11.
Genetic Alterations of the p 53 Gene Are a Feature of Malignant Mesotheliomas 1
TLDR
The correlation of chromosomal loss in 17p on the cytogenetic and molecular level along with p53 mRNA expression and DNA sequence data indicate that genetic alterations in p53 could be a feature of malignant mesotheliomas and may reveal an important role of asbestos fibers in tumor suppressor gene inactivation.
Genetic alterations of the p53 gene are a feature of malignant mesotheliomas.
TLDR
The correlation of chromosomal loss in 17p on the cytogenetic and molecular level along with p53 mRNA expression and DNA sequence data indicate that genetic alterations in p53 could be a feature of malignant mesotheliomas and may reveal an important role of asbestos fibers in tumor suppressor gene inactivation.
p53 protein expression in cutaneous T‐cell lymphomas
TLDR
The findings suggest that molecular and/or genetic alterations of p53 may be implicated in the pathogenesis of high‐grade CTCL, but are unlikely to be of critical importance in low‐gradeCTCL.
P53 protein expression in Hodgkin's disease
TLDR
It is suggested that mutations of the p53 gene and loss of normal p53 function are frequent in Hodgkin's disease and may be implicated in the pathogenesis of this disease.
P53 gene mutations in acute myeloid leukemia with 17p monosomy.
TLDR
The fact that P53 gene mutations occurred more often in patients with 17p monosomy seems to support the "recessive" model of tumor suppressive activity of the P53 genes rather than the "dominant" model, in which alteration of only one allele is sufficient for the development of malignancy.
The role of p53 in malignancy.
TLDR
It is evident that mutations in such a crucial gene are disastrous for the cell, since further lesions in the genome are tolerated and the chance of malignant transformation increases.
Modulation of p53 function by adenovirus E1B58kDa
TLDR
Results from this thesis have indicated that ElB58kDa can modulate some biological activities of wild type p53, but which ones depends on the biological system being studied.
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References

SHOWING 1-10 OF 16 REFERENCES
Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia
Recent studies have demonstrated that the cellular tumour antigen p53 (ref. 1) can complement activated ras genes in the transformation of rat fibroblasts, suggesting that the gene encoding p53 may…
A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
  • A. Dayton, J. Selden, C. Croce
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
The apparent close proximity of the c-erbA sequences to the chromosomal breakpoints in these two leukemias suggests a possible role for this oncogene homologue in the development of these neoplasms.
The gene and the pseudogene for mouse p53 cellular tumor antigen are located on different chromosomes
The chromosomal assignments of the two genes encoding the murine p53 cellular tumor antigen were determined by using a panel of mouse-Chinese hamster somatic cell hybrid clones and a mouse…
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.
TLDR
A DNA probe obtained appears to identify bcl-2, a gene locus on chromosome 18 (band q21) that is unrelated to known oncogenes and may be important in the pathogenesis of B-cell neoplasms with this translocation.
Chromosomal assignment of the murine gene encoding the transformation-related protein p53
TLDR
By analysis of a series of mouse X Chinese hamster hybrid cell lines containing various mouse chromosomes, the p53 gene product is mapped to mouse chromosome 11 by using several independently established anti-p53 monoclonal antibodies.
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
TLDR
It is demonstrated here that p53 can cooperate with the activated Ha-ras oncogene to transform normal embryonic cells, and the resultant foci contain cells of a markedly altered morphology which produce high levels of p53.
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
TLDR
The results indicate that the p53-encoding gene can play a causal role in the conversion of normal fibroblasts into tumorigenic cells, suggesting an important role of p53 in tumorigenesis.
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation.
TLDR
The chromosomal breakpoint of chronic lymphocytic leukemia (CLL) cells of the B-cell type carrying the translocated long arms of chromosomes 11 and 14 [t(11;14) (q13;q32)] was cloned and a gene, named bcl -1, appears to be unrelated to any of the known retrovirus oncogenes described to date.
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.
TLDR
When inserted into SV40‐based expression vectors the human p53 cDNA successfully directs the production of a polypeptide with an apparent mol.
Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
TLDR
Cloned complementary DNA sequences encoding murine p5318 are cloned and reported here that transfection of p53 expression constructs into cells of finite lifespan in vitro results in cellular immortality and susceptibility to transformation by a ras oncogene.
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