Localization of gelsolin proximal to ABL on chromosome 9.

  title={Localization of gelsolin proximal to ABL on chromosome 9.},
  author={David J Kwiatkowski and Carol A. Westbrook and Gail A. P. Bruns and Cynthia C Morton},
  journal={American journal of human genetics},
  volume={42 4},
Gelsolin is a plasma and cytoskeletal protein that severs actin filaments and is regulated by both Ca+2 and polyphosphoinositides. The two forms of gelsolin are encoded by a single gene and derived through alternative message splicing. By Southern blot analysis of somatic cell hybrids and in situ chromosomal localization, we demonstrate that the gelsolin gene is present on human chromosome 9 in bands q32-q34. In situ hybridization of gelsolin to cells containing a Philadelphia chromosome [(9;22… CONTINUE READING


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