• Biology, Medicine
  • Published in Cancer research 1993

Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm.

@article{Bhat1993LocalizationOE,
  title={Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm.},
  author={Hari K. Bhat and Hans Hacker and Peter Bannasch and Emily A Thompson and Joachim G. Liehr},
  journal={Cancer research},
  year={1993},
  volume={53 22},
  pages={
          5447-51
        }
}
The mechanism of estrogen-induced and -dependent kidney carcinogenesis in Syrian hamsters and the cell of origin of the tumor are not well understood; they have been investigated in this study by mapping the cellular locations of estrogen receptor (ER) in estrogen-dependent tumors, in kidney tissue of hamsters treated with estradiol for 0.5 and 5.5 months, and in kidneys of age-matched controls. To validate the methods used, receptors have also been localized in uteri of hamsters and rats and… CONTINUE READING

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