Localization of equilibrative nucleoside transporters in the rat brain.

  title={Localization of equilibrative nucleoside transporters in the rat brain.},
  author={Lauri O Alanko and Tarja Porkka-Heiskanen and Seppo O Soinila},
  journal={Journal of chemical neuroanatomy},
  volume={31 3},
Adenosine is a recognized inhibitory neuromodulator and neuroprotective agent in the central nervous system. It is produced both intra- and extracellularly and transported across the cell membrane. Nucleoside transporters thus have a major impact on the extracellular adenosine levels, and consequently adenosine signalling. We have raised and characterized polyclonal antibodies against both the equilibrative nucleoside transporters 1 and 2, and report for the first time their distribution in rat… CONTINUE READING