Localization of endothelin-like immunoreactivity in the hypothalamo-neurohypophysial system of the rat after ischemia.


Endothelin is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its distribution in the neurosecretory system. Endothelin-like immunoreactivity (EN-IR) has been demonstrated by an immunogold method in the paraventricular and supraoptic nuclear neurons… (More)