Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdala.

@article{Murray2011LocalizationOD,
  title={Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdala.},
  author={Elisabeth A Murray and Steven P. Wise and Wayne C. Drevets},
  journal={Biological psychiatry},
  year={2011},
  volume={69 12},
  pages={e43-54}
}
Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of "self" underlies the core disorder in MDD; the medial frontal cortex represents "self"; interactions between the amygdala and cortical representations update their valuation; and inefficiency in… CONTINUE READING

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