Localization of drug release sites from an oral sustained-release formulation of 5-ASA (Pentasa) in the gastrointestinal tract using gamma scintigraphy.

@article{Hardy1993LocalizationOD,
  title={Localization of drug release sites from an oral sustained-release formulation of 5-ASA (Pentasa) in the gastrointestinal tract using gamma scintigraphy.},
  author={John George Hardy and William J. Harvey and Robert A. Sparrow and Glory B. Marshall and Karen P Steed and M Macarios and Ian R. Wilding},
  journal={Journal of clinical pharmacology},
  year={1993},
  volume={33 8},
  pages={712-8}
}
Release of 5-ASA from a sustained release formulation (Pentasa, Ferring A/S, Copenhagen, Denmark) was monitored with plasma sampling for up to 24 hours in nine volunteers under both fasted and fed conditions. Drug absorption was correlated with location of the sustained-release microgranules in the gastrointestinal tract by gamma scintigraphy… CONTINUE READING