Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.

@article{GhersiEgea1994LocalizationOD,
  title={Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.},
  author={Jean-François Ghersi-Egea and B Leninger-Muller and G Suleman and G{\'e}rard Siest and A. Minn},
  journal={Journal of neurochemistry},
  year={1994},
  volume={62 3},
  pages={1089-96}
}
The brain, with the exception of the choroid plexuses and circumventricular organs, is partially protected from the invasion of blood-borne chemicals by the specific morphological properties of the cerebral micro-vessels, namely, the tight junctions of the blood-brain barrier. Recently, several enzymes that are primarily involved in hepatic drug metabolism have been shown to exist in the brain, albeit at relatively low specific activities. In the present study, the hypothesis that these enzymes… CONTINUE READING
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