Localization of cyclin A at the sites of cellular DNA replication.

@article{SobczakThepot1993LocalizationOC,
  title={Localization of cyclin A at the sites of cellular DNA replication.},
  author={J Sobczak-Thepot and Francis Harper and Y Florentin and Fr{\'e}d{\'e}rique Zindy and Christian Br{\'e}chot and Edmond Puvion},
  journal={Experimental cell research},
  year={1993},
  volume={206 1},
  pages={
          43-8
        }
}
  • J Sobczak-Thepot, Francis Harper, +3 authors Edmond Puvion
  • Published in Experimental cell research 1993
  • Biology, Medicine
  • Cyclin A is a nuclear protein which is part of a kinase complex with either p34cdc2 or p33cdk2. Cyclin A is required in higher eukaryotic cells at the G1/S and the G2/M transitions. To examine the relationship between cyclin A and DNA replication, we simultaneously labeled exponentially growing HeLa cells for the distribution of cyclin A and proliferating cell nuclear antigen (PCNA). We have now demonstrated, by means of immunoelectron microscopy, that cyclin A is located at the sites of DNA… CONTINUE READING

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