Localization of collagenase in human middle ear cholesteatoma.

  title={Localization of collagenase in human middle ear cholesteatoma.},
  author={Maxwell Abramson and Cheng Chun Huang},
  journal={The Laryngoscope},
  volume={87 5 Pt 1},
The process of connective tissue breakdown in chronic otitis media is described in the context of recent advances in our understanding of collagen degradation and bone resorption. The significance of the initial step in collagen breakdown, brought about by the action of a specific collagen dissolving enzyme is emphasized in terms of recent studies in other chronic inflammatory diseases characterized by connective tissue breakdown. Bone resorption, a characteristic feature of chronic otitis… CONTINUE READING


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