Localization of cofilin mRNA to the leading edge of migrating cells promotes directed cell migration.

@article{Maizels2015LocalizationOC,
  title={Localization of cofilin mRNA to the leading edge of migrating cells promotes directed cell migration.},
  author={Yael Maizels and Froma Oberman and Rachel Miloslavski and Nava Ginzach and Malka Berman and Joel K. Yisraeli},
  journal={Journal of cell science},
  year={2015},
  volume={128 10},
  pages={1922-33}
}
mRNA trafficking, which enables the localization of mRNAs to particular intracellular targets, occurs in a wide variety of cells. The importance of the resulting RNA distribution for cellular functions, however, has been difficult to assess. We have found that cofilin-1 mRNA is rapidly localized to the leading edge of human lung carcinoma cells and that VICKZ family RNA-binding proteins help mediate this localization through specific interactions with the 3'UTR of cofilin mRNA. Using a… CONTINUE READING
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