Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme

@article{Wolburg2003LocalizationOC,
  title={Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme},
  author={Hartwig Wolburg and Karen Wolburg-Buchholz and J{\"o}rg Kraus and Gesa Rascher-Eggstein and Stefan Liebner and Stefan Hamm and Frank Duffner and Ernst-H. Grote and Werner Risau and Britta Engelhardt},
  journal={Acta Neuropathologica},
  year={2003},
  volume={105},
  pages={586-592}
}
In the central nervous system (CNS) complex endothelial tight junctions (TJs) form a restrictive paracellular diffusion barrier, the blood-brain barrier (BBB). During inflammation, BBB properties are frequently lost, resulting in brain edema. To investigate whether BBB leakiness correlates with molecular changes at BBB TJs, we performed immunofluorescence stainings for TJ molecules in a mouse model of experimental autoimmune encephalomyelitis (EAE) and in human tissue with glioblastoma… CONTINUE READING
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