Localization of cholinergic and purinergic receptors on outer hair cells isolated from the guinea-pig cochlea.

@article{Housley1992LocalizationOC,
  title={Localization of cholinergic and purinergic receptors on outer hair cells isolated from the guinea-pig cochlea.},
  author={Gary D. Housley and Denise Greenwood and Jonathan F. Ashmore},
  journal={Proceedings. Biological sciences},
  year={1992},
  volume={249 1326},
  pages={265-73}
}
Acetylcholine (ACh) and adenosine 5'-triphosphate (ATP) are shown to act in opposing fashion on guinea-pig cochlear outer hair cells (OHCS) via receptors localized within different fluid compartments of the organ of Corti. The cholinergic (efferent) receptors localized at the basal (perilymphatic) region of these cells activated a rapidly desensitizing hyperpolarizing K+ current. In contrast, purinergic (ATP) receptors were localized at the apical (endolymphatic) surface of OHCS and activated a… CONTINUE READING