Localization of an exchangeable GTP binding site at the plus end of microtubules.

@article{Mitchison1993LocalizationOA,
  title={Localization of an exchangeable GTP binding site at the plus end of microtubules.},
  author={Timothy J Mitchison},
  journal={Science},
  year={1993},
  volume={261 5124},
  pages={1044-7}
}
Microtubule polarity arises from the head-to-tail orientation of alpha-beta tubulin heterodimers in the microtubule lattice. The identity of the polypeptide at each end of the microtubule is unknown, but structural models predict that the beta-tubulin end contains an exchangeable guanosine triphosphate (GTP) binding site. When GTP-coated fluorescent beads were incubated with microtubules, they bound specifically to plus ends, suggesting that tubulin is oriented in microtubules with beta-tubulin… CONTINUE READING

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