Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons.

@article{Shigematsu1992LocalizationOA,
  title={Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons.},
  author={Kazuto Shigematsu and Patrick L. Mcgeer and E. G. McGeer P. L. McGeer},
  journal={Brain research},
  year={1992},
  volume={592 1-2},
  pages={353-7}
}
One of the hallmarks of Alzheimer pathology is extracellular deposition of beta-amyloid protein (BAP) which is derived from a larger glycoprotein called amyloid precursor protein (APP). Although APP has often been described as a surface membrane protein, such a localization has not previously been demonstrated at the light or electron microscopic level. We now report the results of immunoelectron microscopy using three specific antibodies against different synthetic fragments of APP. All three… CONTINUE READING

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