Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors.

@article{Liaw1997LocalizationOA,
  title={Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors.},
  author={Chen W Liaw and D. G. E. Grigoriadis and Marge T Lorang and Errol B De Souza and Richard A Maki},
  journal={Molecular endocrinology},
  year={1997},
  volume={11 13},
  pages={
          2048-53
        }
}
The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily. Despite their considerable sequence similarity, CRFR1 and CRFR2 have quite different affinities for the peptide ligand rat/human CRF. Previous studies using chimeric receptors between human CRFR1 and CRFR2 have identified three potentially important regions in the second and third extracellular domains of CRF receptor for the binding of rat/human CRF. The present report further demonstrates that these… CONTINUE READING
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