Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH.

@article{Mizutani2009LocalizationOA,
  title={Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH.},
  author={M. Mizutani and K. Atsuchi and A. Asakawa and N. Matsuda and M. Fujimura and A. Inui and I. Kato and M. Fujimiya},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={297 5},
  pages={
          G974-80
        }
}
Acyl ghrelin has a 28-amino acid sequence with O-n-octanoyl acid modification at the serine 3 position, whereas des-acyl ghrelin has no octanoyl acid modification. Although these peptides exert different physiological functions, no previous studies have shown the different localization of acyl ghrelin and des-acyl ghrelin in the stomach. Here we have developed an antibody specific for des-acyl ghrelin that does not crossreact with acyl ghrelin. Both acyl ghrelin- and des-acyl ghrelin… Expand
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