Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.

@article{Owerbach1993LocalizationOA,
  title={Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.},
  author={David Owerbach and Kenneth H Gabbay},
  journal={Diabetes},
  year={1993},
  volume={42 12},
  pages={1708-14}
}
A susceptibility gene for type I diabetes is present on chromosome 11p15.5, but its location, identity, and mechanism of action are unknown. We have sequenced 14 kilobases of DNA flanking the human insulin gene and found new DNA polymorphisms and determined their frequencies in the general population and in families of type I diabetic subjects. A DNA polymorphism located 3123 base pairs downstream from the initiation site of transcription of the insulin gene, when present in the homozygous… CONTINUE READING

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