Localization of a new enteric non-A, non-B [HEV] virus in target organ liver

  title={Localization of a new enteric non-A, non-B [HEV] virus in target organ liver},
  author={H Gupta and Bhanu Iyenger and Badri Nath Tandon},
  journal={Gastroenterologia Japonica},
SummaryThirteenMacaca mulatta monkeys were used for transmission of enteric non-A, non-B hepatitis virus (HEV) by the portal vein (PV) route. All these animals developed changes which are found in selflimiting acute viral hepatitis e.g. rise in liver enzymes, the presence of HEV specific viral particles in the stool and histological changes in the liver from 21 to 45 days after HEV inoculation. All the animals recovered completely as reflected by normalization of liver enzymes, and regenerative… 
2 Citations
Metabonomic analysis of hepatitis E patients shows deregulated metabolic cycles and abnormalities in amino acid metabolism
Findings may help better understand the clinical and biochemical manifestations in this disease and the underlying pathophysiologic processes and it would be worthwhile determining whether patients with hepatitis E are more prone to develop lactic acidosis and ketosis compared with other forms of viral hepatitis.


Enterically transmitted non-A, non-B hepatitis in cynomolgus monkeys: morphology and probable mechanism of hepatocellular necrosis.
Morphological analysis of in vitro and in vivo transmission studies in cynomolgus monkeys strongly supported the hypothesis of immune-mediated hepatocytolysis rather than a direct cytopathic effect of this hepatitis virus.
Animal transmission of enteric non-A, non-B hepatitis infection to Macaca mulatta by faeco-oral route.
Biochemical, histopathological and serological changes were seen in the blood and liver and excretion of 27 nm virus like particles around 27 days of inoculation in the experimental monkey but not in the control animal.
Transmission of enteric non‐A, non‐B hepatitis virus in Macaca mulatta, monkeys by intraportal route: Subsequent passages of HEV virus
All monkeys developed acute hepatitis, as evidenced by transient elevation of aminotransferases, histopathological changes in the liver, development of antibodies aggregating 27–34 nm VLP and excretion of 27– 34 nm V LP in stools.
Serial transmission of a putative causative virus of enterically transmitted non-A, non-B hepatitis to Macaca fascicularis and Macaca mulatta.
Macaca fascicularis inoculated with a fecal extract obtained from Myanmar patients with acute sporadic non-A, non-B hepatitis showed an aggregation of virus-like particles, which appears to be a new hepatitis virus.
Aetiological agent of enterically transmitted non-A, non-B hepatitis.
Findings indicate that one virus or class of viruses is responsible for the majority of enterically transmitted non-A, non-B hepatitis (ET-NANBH).
Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis.
Et1.1 represents a portion of the genome of the principal viral agent, to be named hepatitis E virus, which is responsible for epidemic outbreaks of ET-NANBH, and specifically identified similar sequences in complementary DNA prepared from infected human fecal samples collected from five geographically distinct ET- NANH outbreaks.
Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets.
An epidemic of non-A, non-B hepatitis occurred in Kathmandu Valley, Nepal, during 1981-1982, with approximately 7.6% of households and 1.4% of individuals affected. Cases occurred preponderantly in
Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route.
Intravenous inoculation of cynomolgus monkeys with the virus-containing stool extract resulted in histopathologically and enzymatically confirmed hepatitis, excretion of virus-like particles, and antibody response to them.
Enterically-transmitted non-A, non-B hepatitis.
  • D. Bradley
  • Medicine, Biology
    British medical bulletin
  • 1990
Accumulating evidence suggests that a high proportion of this non-A, non-B hepatitis (NANB) is enterically transmitted and is caused by one virus or class of serologically related viruses.
Enterically transmitted non-A, non-B hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27- to 34-nm viruslike particles.
The findings indicate that cynomolgus macaques are particularly suitable experimental models for studies of human ET-NANBH, and the 27- to 34-nm VLPs found in infected human and primate stools appear to be etiologically linked to disease.