Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene.

@article{Malkoski1997LocalizationOA,
  title={Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene.},
  author={Stephen P Malkoski and C M Handanos and R. Dorin},
  journal={Molecular and cellular endocrinology},
  year={1997},
  volume={127 2},
  pages={189-99}
}
Corticotropin releasing hormone (CRH) plays a primary role in mediating suprapituitary activation of the hypothalamic-pituitary-adrenal axis and is an important physiologic target of negative feedback regulation by glucocorticoids. We sought to define cis-acting regions of the CRH promoter responsible for cAMP-dependent activation and glucocorticoid-dependent repression of CRH promoter activity. In transiently transfected AtT-20 cells, cAMP-dependent transcriptional activation was mediated… CONTINUE READING