Localization of a gene responsible for nonspecific mental retardation (MRX9) to the pericentromeric region of the X chromosome.

@article{Willems1993LocalizationOA,
  title={Localization of a gene responsible for nonspecific mental retardation (MRX9) to the pericentromeric region of the X chromosome.},
  author={Patrick J. Willems and Lieve Vits and I. M. Buntinx and Peter Raeymaekers and Christine van Broeckhoven and B{\'e}n{\'e}dicte Ceulemans},
  journal={Genomics},
  year={1993},
  volume={18 2},
  pages={
          290-4
        }
}
Nonspecific X-linked mental retardation (MRX) includes several distinct entities with mental retardation but without additional distinguishing features. The MRX family reported here has been classified previously as MRX9. In this study, we performed linkage analysis of MRX9 with a panel of 43 polymorphic DNA markers dispersed over chromosome X. Two-point linkage analysis revealed lod scores of 3.52 and 3.82 at 0% recombination for OATL1 and MAOA, both located in Xp11.2-p11.4. Lod scores for… CONTINUE READING