Localization of a calcium sensitive binding site for gelsolin on actin subdomain I: implication for severing process.

@article{Feinberg1997LocalizationOA,
  title={Localization of a calcium sensitive binding site for gelsolin on actin subdomain I: implication for severing process.},
  author={Jacqueline Feinberg and M. C. Lebart and Yves Benyamin and Claude Roustan},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={233 1},
  pages={61-5}
}
The binding of the N-terminal domain (S1) of gelsolin to monomeric actin has been extensively documented. In contrast, the location of the C-terminal calcium dependent domains (S4-6) interacting with the actin filament during the severing process remains uncertain. In this study, we have identified a new interface that supports calcium dependent gelsolin… CONTINUE READING