Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.

@article{Iida1997LocalizationOA,
  title={Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.},
  author={Asako Iida and Ryuichi Isobe and Masataka Yoshimoto and Fujio Kasumi and Yusuke Nakamura and Mitsuru Emi},
  journal={British Journal of Cancer},
  year={1997},
  volume={75},
  pages={264 - 267}
}
Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515… CONTINUE READING