Localization of a Collagen-Interactive Domain of Human von Willebrand Factor Between Amino Acid Residues Gly 911 and Glu 1

Abstract

A collagen-binding domain of von Willebrand factor (vWF) has been identified in the central part of the molecule by comparing the binding properties of vWF and Staphylococcus aureus V-8 protease-generated vWF fragments with collagen. The binding of purified human vWF to human type Ill collagen was found to be specific. At saturation. 38 to 50.2 zg of vWF… (More)

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