Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen.

@article{OConnell2006LocalizationOT,
  title={Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen.},
  author={Catherine M O'Connell and Irina A. Ionova and Alison J Quayle and Alberto Visintin and Robin R. Ingalls},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 3},
  pages={1652-9}
}
Chlamydia trachomatis is an obligate intracellular gram-negative pathogen and the etiologic agent of significant ocular and genital tract diseases. Chlamydiae primarily infect epithelial cells, and the inflammatory response of these cells to the infection directs both the innate and adaptive immune response. This study focused on determining the cellular immune receptors involved in the early events following infection with the L2 serovar of C. trachomatis. We found that dominant negative MyD88… CONTINUE READING
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