Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR

@article{Helms2005LocalizationOP,
  title={Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR},
  author={Cynthia Helms and Nancy L. Saccone and Li Cao and Jil A. Wright. Daw and Kai Ming Cao and Tony M. Hsu and Patricia Taillon-Miller and Shenghui Duan and Derek Gordon and Brandon L Pierce and J{\"u}rg Ott and John Irving visited Rice and Marcelo An{\'i}bal Fern{\'a}ndez-Vi{\~n}a and Pui-Yan Kwok and Alan Menter and Anne M Bowcock},
  journal={Human Genetics},
  year={2005},
  volume={118},
  pages={466-476}
}
Psoriasis is a complex inflammatory disease of the skin affecting 1–2% of the Caucasian population. Associations with alleles from the HLA class I region (now known as PSORS1), particularly HLA-Cw*0602, were described over 20 years ago. However, extensive linkage disequilibrium (LD) within this region has made it difficult to identify the true susceptibility allele from this region. A variety of genes and regions from a 238-kb interval extending from HLA-B to corneodesmosin (CDSN) have been… CONTINUE READING