Localization of P2X1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys.

  title={Localization of P2X1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys.},
  author={Choong Meng Chan and Robert J Unwin and Michelle Bardini and Ian Oglesby and Anthony P. D. W. Ford and Andrea Townsend-Nicholson and Geoffrey Burnstock},
  journal={American journal of physiology. Renal physiology},
  volume={274 4},
P2 receptors have been identified in rat kidney by autoradiography, using the radioligand [3H]α,β-methylene ATP, and by immunohistochemistry, using a polyclonal antibody to the P2X1 purinoceptor. They have been localized to the vascular smooth muscle of intrarenal arteries, including arcuate and interlobular arteries, and afferent arterioles, but not glomeruli, postglomerular efferent arterioles, or renal tubules. We conclude that at least some of the P2 receptors present on vascular smooth… CONTINUE READING


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