Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat.

@article{Yoo2006LocalizationON,
  title={Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat.},
  author={Shin Young Yoo and Halina Dobrzynski and Vadim V. Fedorov and Shang-zhong Xu and Tomoko T. Yamanushi and Sandra A Jones and Mitsuru Yamamoto and Vladmir P Nikolski and Igor R. Efimov and Mark R. Boyett},
  journal={Circulation},
  year={2006},
  volume={114 13},
  pages={
          1360-71
        }
}
BACKGROUND The electrical activity of the atrioventricular node (AVN) is functionally heterogeneous, but how this relates to distinct cell types and the 3-dimensional structure of the AVN is unknown. To address this, we have studied the expression of Na(V)1.5 and other Na+ channel isoforms in the AVN. METHODS AND RESULTS The rat AVN was identified by Masson's trichrome staining together with immunolabeling of marker proteins: connexin40, connexin43, desmoplakin, atrial natriuretic peptide… CONTINUE READING

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