Localization of N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) expression in mouse brain: A new perspective on N‐acylethanolamines as neural signaling molecules

@article{Egertov2008LocalizationON,
  title={Localization of N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) expression in mouse brain: A new perspective on N‐acylethanolamines as neural signaling molecules},
  author={Michaela Egertov{\'a} and Gabriel M. Simon and Benjamin F. Cravatt and Maurice R. Elphick},
  journal={Journal of Comparative Neurology},
  year={2008},
  volume={506}
}
N‐acylethanolamines (NAEs) are membrane‐derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide). An N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) that catalyzes formation of NAEs was recently identified as a member of the zinc metallohydrolase family of enzymes. NAPE‐PLD−/− mice have greatly reduced brain levels of long‐chain saturated NAEs but wild‐type levels of polyunsaturated NAEs (e.g., anandamide), suggesting an… 
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Enzymatic formation of anandamide.
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