Localization of Menkes gene expression in the mouse brain; its association with neurological manifestations in Menkes model mice

  title={Localization of Menkes gene expression in the mouse brain; its association with neurological manifestations in Menkes model mice},
  author={Toshio Iwase and Masahiko Nishimura and Haruhiko Sugimura and Hisaki Igarashi and Fukujiro Ozawa and Kazuya Shinmura and Makoto Suzuki and Masamitsu Tanaka and Isamu Kino},
  journal={Acta Neuropathologica},
Menkes gene (Mc1 or MNK, encoding putative copper-transporting ATPase) expression was investigated and compared in normal and macular mutant mouse brain. Northern blot analysis showed a distinct 8.3-kb transcript and no obvious difference in size or extent in normal mice and macular mutants on postnatal days 0, 4, 7, 10 or 13. In situ hybridization revealed that certain specific populations of cells in the brain express Menkes mRNA, and that their localization in normal and mutant mice did not… CONTINUE READING
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