Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels

@inproceedings{Sengupta2011LocalizationOM,
  title={Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels},
  author={Anamika Sengupta and Kenkichi Baba and Francesca Mazzoni and Nikita V. Pozdeyev and Enrica Strettoi and Paul Michael Iuvone and Gianluca Tosini},
  booktitle={PloS one},
  year={2011}
}
Melatonin modulates many important functions within the eye by interacting with a family of G-protein-coupled receptors that are negatively coupled with adenylate cyclase. In the mouse, Melatonin Receptors type 1 (MT(1)) mRNAs have been localized to photoreceptors, inner retinal neurons, and ganglion cells, thus suggesting that MT(1) receptors may play an important role in retinal physiology. Indeed, we have recently reported that absence of the MT(1) receptors has a dramatic effect on the… CONTINUE READING
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