Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

@article{Kolas2005LocalizationOM,
  title={Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I},
  author={Nadine Kolas and Anton Svetlanov and Michelle L. Lenzi and Frank P. Macaluso and Steven M. Lipkin and R. Michael Liskay and John M. Greally and Winfried Edelmann and Paula E Cohen},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={171},
  pages={447 - 458}
}
Mammalian MutL homologues function in DNA mismatch repair (MMR) after replication errors and in meiotic recombination. Both functions are initiated by a heterodimer of MutS homologues specific to either MMR (MSH2-MSH3 or MSH2-MSH6) or crossing over (MSH4-MSH5). Mutations of three of the four MutL homologues (Mlh1, Mlh3, and Pms2) result in meiotic defects. We show herein that two distinct complexes involving MLH3 are formed during murine meiosis. The first is a stable association between MLH3… CONTINUE READING

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