Localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in human coronal dentine.

  title={Localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in human coronal dentine.},
  author={Lina Niu and Ling Zhang and Kai Jiao and Fang Li and Yu Xin Ding and Daniel Y Wang and Megakaryopoiesis Qi Wang and Franklin Russel Tay and Jiann Heng Chen},
  journal={Journal of dentistry},
  volume={39 8},
OBJECTIVES Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play important roles in dentine formation, caries progression and hybrid layer degradation. This study tested the hypothesis that the distribution and concentrations of MMP-2, MMP-9, TIMP-1 and TIMP-2 are different at different depths of human coronal dentine, including odontoblasts. METHODS Protein localization was performed using immunohistochemistry. Co-localization of the MMPs and their inhibitors was conducted using… CONTINUE READING
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