Localization of HSP47 mRNA in murine bleomycin-induced pulmonary fibrosis

  title={Localization of HSP47 mRNA in murine bleomycin-induced pulmonary fibrosis},
  author={Tomoyuki Kakugawa and Hiroshi Mukae and Yoshitaka Hishikawa and Hiroshi Ishii and Noriho Sakamoto and Yuji Ishimatsu and Takeshi Fujii and Takehiko Koji and Shigeru Kohno},
  journal={Virchows Archiv},
Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that has been shown to play a major role in the processing and/or secretion of procollagen. However, the knowledge on which cells are actually synthesizing HSP47 in the lung parenchyma in pulmonary fibrosis was only limited. The aim of the present study was to investigate the localization of HSP47 messenger ribonucleic acid (mRNA) in normal lung and in the lungs of mice in bleomycin-induced pulmonary fibrosis, using in… CONTINUE READING
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