Localization of Canine Brachycephaly Using an Across Breed Mapping Approach

  title={Localization of Canine Brachycephaly Using an Across Breed Mapping Approach},
  author={Danika L. Bannasch and Amy N. Young and Jeffrey Myers and Katarina Truv{\'e} and Peter Dickinson and Jeffrey Paul Gregg and Ryan Davis and Eric Bongcam-Rudloff and Matthew T Webster and Kerstin Lindblad-Toh and Niels Egholm Pedersen},
  booktitle={PloS one},
The domestic dog, Canis familiaris, exhibits profound phenotypic diversity and is an ideal model organism for the genetic dissection of simple and complex traits. However, some of the most interesting phenotypes are fixed in particular breeds and are therefore less tractable to genetic analysis using classical segregation-based mapping approaches. We implemented an across breed mapping approach using a moderately dense SNP array, a low number of animals and breeds carefully selected for the… CONTINUE READING


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