Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography.

@article{Eftekhari2016LocalizationOC,
  title={Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography.},
  author={Sajedeh Eftekhari and Renee C. Gaspar and Rhonda Roberts and Tsing-Bau Chen and Zhizhen Zeng and Stephanie A Villarreal and Lars Edvinsson and Christopher A. Salvatore},
  journal={The Journal of comparative neurology},
  year={2016},
  volume={524 1},
  pages={90-118}
}
Functional imaging studies have revealed that certain brainstem areas are activated during migraine attacks. The neuropeptide calcitonin gene-related peptide (CGRP) is associated with activation of the trigeminovascular system and transmission of nociceptive information and plays a key role in migraine pathophysiology. Therefore, to elucidate the role of CGRP, it is critical to identify the regions within the brainstem that process CGRP signaling. In situ hybridization and immunofluorescence… CONTINUE READING
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