Localization of BRCA1 and a splice variant identifies the nuclear localization signal.

@article{Thakur1997LocalizationOB,
  title={Localization of BRCA1 and a splice variant identifies the nuclear localization signal.},
  author={S Thakur and Hong Zhang and Yuan-ying Peng and Huong Le and Bryan T Carroll and Theresa H Ward and Ji-hua Yao and Linda M. Farid and Fergus J. Couch and Russell B. Wilson and Barbara L. Weber},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 1},
  pages={444-52}
}
Inherited mutations in BRCA1 confer susceptibility to breast and ovarian neoplasms. However, the function of BRCA1 and the role of BRCA1 in noninherited cancer remain unknown. Characterization of alternately spliced forms of BRCA1 may identify functional regions; thus, we constructed expression vectors of BRCA1 and a splice variant lacking exon 11, designated BRCA1 delta 672-4095. Immunofluorescence studies indicate nuclear localization of BRCA1 but cytoplasmic localization of BRCA1 delta 672… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Similar Papers

Loading similar papers…