Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.

@article{Li2008LocalizationOA,
  title={Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.},
  author={Lian-Yun Li and Dale Warren Hailey and Nia Soetandyo and Wei Li and Jennifer Lippincott-Schwartz and Hong-Bing Shu and Yihong Ye},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1783 6},
  pages={1140-9}
}
A20 is a tumor necrosis factor (TNF)-inducible zinc finger protein that contains both ubiquitinating and deubiquitinating activities. A20 negatively regulates NFkappaB (nuclear factor kappaB) signaling induced by TNF receptor family and Toll-like receptors, but the mechanism of A20 action is poorly defined. Here we show that a fraction of endogenous and ectopically expressed A20 is localized to an endocytic membrane compartment that is in association with the lysosome. The lysosomal association… CONTINUE READING