Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.

@article{Brock1994LocalizationO5,
  title={Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.},
  author={Thomas G. Brock and Robert Paine and Marc Peters-Golden},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 35},
  pages={22059-66}
}
Arachidonate metabolism by 5-lipoxygenase (5-LO) coincides with the translocation of the enzyme from a soluble to a pelletable fraction in thoroughly disrupted granulocytic cells. While immunoelectron microscopy has identified the nuclear membrane as the site at which 5-LO, as well as 5-LO activating protein (FLAP), are localized in activated cells, the locale of soluble 5-LO in unstimulated cells could not be established by this technique. We asked whether the nucleus might also be the site… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…