Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum

@article{Geurts2002LocalizationO5,
  title={Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum},
  author={Frederik Joris Geurts and Erik De Schutter and Jean-Pierre Timmermans},
  journal={Journal of Chemical Neuroanatomy},
  year={2002},
  volume={24},
  pages={65-74}
}

Figures and Tables from this paper

Building a 5-HT3A Receptor Expression Map in the Mouse Brain

A 5-HT3AR expression map in the mouse brain is built and double-immunostaining using neural markers confirmed that 5- HT3AR is expressed in GABAergic interneurons containing somatostatin or calretinin.

Distinct Temporal Expression of 5-HT1A and 5-HT2A Receptors on Cerebellar Granule Cells in Mice

A novel role for serotonin in controlling function of the cerebellum via 5-HT2A receptors expressed by cerebellar granule cells is shown, which enhances short-term synaptic plasticity at the parallel fibre–Purkinje cell synapse.

Evidence for the differential co-localization of neurokinin-1 receptors with 5-HT receptor subtypes in rat forebrain

These experiments demonstrate a high degree of co-localization between NK1Rs and 5-HT1A receptors in cortical and limbic regions of the rat forebrain, and suggest a novel site of interaction betweenNK1R antagonists and the5-HT system.

5-HT2A receptor-mediated excitation on cerebellar fastigial nucleus neurons and promotion of motor behaviors in rats

It is shown that only 5-HT2A receptors among the 5- HT2 receptor subfamily are expressed and localized in the rat cerebellar fastigial nucleus (FN), one of the ultimate outputs of the spinocerebellum precisely regulating trunk and limb movements.

5-ht5A receptors as a therapeutic target.

UvA-DARE Distinct Temporal Expression of 5-HT1A and 5-HT 2A Receptors on Cerebellar Granule Cells in Mice

A novel role for serotonin in controlling function of the cerebellum via 5-HT 2A receptors expressed by cerebellar granule cells is shown, which enhances short-term synaptic plasticity at the parallel fibre – Purkinje cell synapse.

Serotonin and Synaptic Transmission in the Cerebellum

This article proposes that 5-HT widely modulates the information flow from Purkinje cells in the cerebellar cortex, and also suppresses synaptic transmission and the expression of long-term synaptic plasticity in DCN neurons.
...

References

SHOWING 1-10 OF 72 REFERENCES

Distribution of the 5-HT5A serotonin receptor mRNA in the human brain.

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

Direct evidence for the existence of 5-HT3 receptors in rat brain tissue and their distribution is reported, based on high affinity binding of the potent 5- HT3 receptor antagonist 3H-GR65630 to homogenates of rat entorhinal cortex.

Immunocytochemical localization of 5-HT1A receptors in the rat immature cerebellum.

The serotonin 5-HT1A receptors were visualized in the cerebellar vermis of 8-day-old and adult rats by immunocytochemistry using anti-5-HT1A receptor antibodies raised against a synthetic peptide

Expression of serotonin 5‐HT2A receptors in the human cerebellum and alterations in schizophrenia

Cerebellar 5‐HT2AR gene products (mRNA, protein, binding sites) are expressed in the human cerebellum at nonnegligible levels; this bears upon 5‐ HT2AR imaging studies which use the cerebellums as a reference region.
...