Localization in situ of the co-stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue.

@article{VythDreese1995LocalizationIS,
  title={Localization in situ of the co-stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue.},
  author={Florry A. Vyth-Dreese and Trees A. M. Dellemijn and Donn{\'e} M. Majoor and Daphne D de Jong},
  journal={European journal of immunology},
  year={1995},
  volume={25 11},
  pages={3023-9}
}
Functional interactions between B and T lymphocytes are known to depend on the expression of co-stimulatory molecules B7.1/CD80, B7.2/CD86 and their counter-receptors CD28 and CTLA4, as well as CD40 and its ligand CD40L. To study the role of these molecules in situ, an immunohistochemical analysis was carried out on normal human lymphoid tissue. In the germinal centers (GC), B7.1 and B7.2 were differentially expressed. In the dark zone, centroblasts were predominantly B7.1+, while centrocytes… CONTINUE READING