Localization and temporal expression of prolactin receptor in human endometrium.

@article{Jones1998LocalizationAT,
  title={Localization and temporal expression of prolactin receptor in human endometrium.},
  author={R L Jones and Hilary O. D. Critchley and Julie Brooks and Henry N. Jabbour and Alan S. Mcneilly},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 1},
  pages={
          258-62
        }
}
Extrapituitary PRL is synthesized by the decidualized endometrial stromal cells from the mid to late secretory phase in the nonpregnant cycle and throughout pregnancy. The function of PRL in the uterus is unknown, but the temporal expression indicates a role in implantation and placentation. PRL is a powerful immunoregulatory agent, and thus, a role in modulating endometrial leukocytes may be envisaged. To investigate the site of action of PRL, immunohistochemistry was conducted to localize the… 
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Expression of prolactin and its receptor in the baboon uterus during the menstrual cycle and pregnancy.
TLDR
The baboon is established as a nonhuman primate model to investigate the potential roles of PRL in implantation and maintenance of pregnancy and demonstrates that the baboon uterus is a site of both PRL production and action during the cycle and pregnancy.
Localization and signaling of the prolactin receptor in the uterus of the common marmoset monkey.
TLDR
The site of expression of PRL, PRL receptors, and IRF-1 in the marmoset uterus suggest that PRL may influence glandular epithelial function and direct gene transcription in these cells in a paracrine fashion.
Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin.
TLDR
An up-regulation of expression of functional PRL receptors during the secretory phase of the menstrual cycle is demonstrated and decidual PRL through a paracrine mechanism may influence glandular epithelial function/secretions and direct gene transcription through the JAK/STAT pathway.
Prolactin Receptor and Uterine Milk Protein Expression in the Ovine Endometrium During the Estrous Cycle and Pregnancy1
TLDR
It is proposed that activation of PRL-R signal transduction pathways by PRL and PL plays a major role in endometrial GE remodeling and differentiated function during pregnancy in support of conceptus growth and development.
Prolactin receptor gene expression and immunolocalization of the prolactin receptor in human luteinized granulosa cells.
TLDR
The presence of PRL-R in human luteinized granulosa cells is confirmed and a localized role for PRL within the mature follicle is suggested, suggesting that the effects of prolactin are exerted around the time of ovulation.
Lack of expression of endometrial prolactin in early implantation failure: a pilot study.
TLDR
A lack of expression of endometrial prolactin during the 'implantation window' in some patients affected by unexplained infertility and repeated miscarriages is reported, suggesting that the lack ofendometrial PRL expression is involved in reproduction failure.
Prolactin induces ERK phosphorylation in epithelial and CD56(+) natural killer cells of the human endometrium.
TLDR
The data demonstrate that PRL stimulates the ERK pathway in multiple cellular compartments of the human endometrium and identify uterine CD56(+) NK cells as novel PRL target cells.
Prolactin receptor expression and signalling in the marmoset monkey uterus
TLDR
The purpose of the research presented in this thesis was to investigate the expression and signalling pathway of PRL and its receptor (PRL-R) in the non-pregnant uterus of the common marmoset monkey 0Callithrix jacchus and to establish whether PRL intracellular signalling is associated with uterine function of the marmosett monkey.
Prolactin Enhances the Proliferation of Proliferative Endometrial Glandular Cells and Endometrial Cancer Cells
TLDR
Low levels of prolactin-PRLR signaling via MAPK may play a crucial role in the progression of EC in hyperprolactinemic women.
Neonatal Ovine Uterine Development Involves Alterations in Expression of Receptors for Estrogen, Progesterone, and Prolactin1
TLDR
The hypothesis that neonatal ovine uterine development involves epithelial PRL-R and ER-α activation to stimulate and maintain endometrial gland genesis and branching morphogenesis is supported.
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References

SHOWING 1-10 OF 51 REFERENCES
The human prolactin receptor in the fetal membranes, decidua, and placenta.
TLDR
This study shows that the PRL-R is widely expressed by both fetal and maternal tissues in late pregnancy and its increased expression during labor and delivery in the chorion, decidua, and placenta supports an autocrine/paracrine role for decidual PRL in the peripartum.
Expression of decidual prolactin-related protein in the rat decidua.
TLDR
The results of this investigation revealed that the expression of dPRP in endometrial stromal cells is triggered by the induction of decidualization and that this gene is selectively and abundantly expressed in a defined cell population located in the anti-mesometrial region of the uterus.
The relationship between decidualization and prolactin mRNA and production at different stages of human pregnancy.
TLDR
There is a close link between the level of prolactin gene expression and production of Prolactin by individual decidual cells, which in turn is directly related to the process of decdualization that continues throughout human pregnancy.
Prolactin production during in vitro decidualization of proliferative endometrium.
Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma.
TLDR
It is demonstrated in a variety of cell types, including lymphocytes and endometrial stroma, that Pit-1 is not involved in the regulation of dPRL promoter/reporter gene constructs carrying 3 kb 5'-flanking DNA, and experiments show that activated PR does not confer direct transcriptional control on the d PRL promoter.
Prolactin production by human endometrium during the normal menstrual cycle.
Expression and localization of prolactin messenger ribonucleic acid in the human immune system.
TLDR
The presence of PRL mRNA in human lymphoids tissue implies that locally synthesized PRL may play a critical role in immunocompetence by providing an important regulatory signal to the microenvironment of human lymphoid organs.
Expression and hormone regulation of prolactin receptors in rat dorsal and lateral prostate.
TLDR
Testosterone (T), estrogen (E), and PRL regulation of PRL receptor expression in rat DP and LP was studied in organ culture, which has been shown to be a suitable model to study hormone responses of prostatic tissue in vitro.
Human prolactin gene expression. The use of an alternative noncoding exon in decidua and the IM-9-P3 lymphoblast cell line.
Chemokine and cyclooxygenase-2 expression in human endometrium coincides with leukocyte accumulation.
TLDR
Results from the present study further support the hypothesis that there is a premenstrual migration of leukocytes into the endometrium mediated by chemokines.
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