Localization and synthesis of an insulin-binding region on human insulin receptor.


Seven regions of the alpha subunit of human insulin receptor (HIR) were synthesized and examined for their ability to bind radioiodinated insulin. A peptide representing one of these regions (namely, residues alpha 655-670) exhibited a specific binding activity for insulin. In quantitative radiometric titrations, the binding curves of 125I-labeled insulin… (More)


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