Localization and sequence analysis of poly(A) sites generating multiple dihydrofolate reductase mRNAs.

@article{Hook1988LocalizationAS,
  title={Localization and sequence analysis of poly(A) sites generating multiple dihydrofolate reductase mRNAs.},
  author={A G Hook and Rodney E. Kellems},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 5},
  pages={2337-43}
}
The murine dihydrofolate reductase (DHFR) gene gives rise to multiple polyadenylated mRNAs displaying heterogeneity in the length of the 3' untranslated region. These species are present in the cytoplasm at levels that vary over 2 orders of magnitude, suggesting that certain poly(A) sites are preferred over others. Previous observations have shown that three out of the four major sites of polyadenylation do not display consensus hexanucleotide (AATAAA, ATTAAA) signals. We have further analyzed… CONTINUE READING